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Coagulation ａnd Anti-coagulation Compound Library

MCE 站：Coagulation ａnd Anti-coagulation Compound Library

Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately ａnd evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system ａnd participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation. Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site ａnd anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis ａnd treatment of the abnormal coagulation process.MCE supplies a unique collection of 744 compounds targeting key proteins in coagulation ａnd anti-coagulation system. MCE Coagulation ａnd Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation ａnd anticoagulation.

Description & Advantages:

    A unique collection of 744 Coagulation ａnd Anti-coagulation related compounds for high throughput screening (HTS) ａnd high content screening (HCS).

    A useful tool to screen new inhibitors of coagulation ａnd anti-coagulation.

   Target diverse, medicinally active ａnd cell permeable.

   Bioactivity ａnd safety confirmed by preclinical research ａnd clinical trials.

   More detailed compound information with structure, IC50, ａnd other chemical & biological data.

   High purity ａnd quality validated by NMR ａnd LC/MS.

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   40,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。