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Cergutuzumab amunaleukin

CAS No. : 1509916-03-3

MCE 站：Cergutuzumab amunaleukin

产品活性：Cergutuzumab amunaleukin (CEA-IL2v) 是一种基于癌胚抗原 (CEA) 靶向 IL-2 变体的免疫细胞因子。Cergutuzumab amunaleukin 具有免疫刺激和抗肿瘤活性。

研究领域：Immunology/Inflammation

作用靶点：Interleukin Related

In Vitro: Cergutuzumab amunaleukin comprises a single IL-2 variant (IL2v) moiety with abolished CD25 binding, fused to the C-terminus of a high affinity, bivalent CEA-specific antibody devoid of Fc-mediated effector functions. Its molecular design aims to avoid preferential activation of regulatory T-cells vs. immune effector cells by removing CD25 binding.
The activation of NK cells by Cergutuzumab amunaleukin (CEA-IL2v; 0.001-1000 nM) translated into increased killing of the CEA-positive colon cancer cell line LS180 accompanied by increased release of Granzyme B, IFNγ ａnd RANTES ａnd upregulation of CD25 ａnd CD69 on NK cells.

In Vivo: In tumor-free mice, a strong expansion of peripheral CD⁸⁺ T ａnd NK cells after treatment with 0.5 ａnd 2 mg/kg Cergutuzumab amunaleukin (CEA-IL2v; i.v.; once) is observed.

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