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c-Myc inhibitor 8

CAS No. : 2173505-97-8

MCE 站：c-Myc inhibitor 8

产品活性：c-Myc inhibitor 8 (compound 56) 是一种 c-Myc 抑制剂。c-Myc inhibitor 8 有效抑制多种癌细胞的细胞活力。c-Myc inhibitor 8 在小鼠模型中抑制人前列腺癌和肺癌肿瘤的生长。c-Myc inhibitor 8 可用于癌症研究。

研究领域：Apoptosis

作用靶点：c-Myc

In Vitro: c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of KU-19-19, 253J, J82, Τ24, ΜΒΤ-2 ａnd UM-UC-3 bladder cancer cell lines with IC₅₀s of 0.90, 1.11, 1.46, 0.98, 1.18 ａnd 1.25 μM, respectively.
c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of Α549, NCI-H460, MRC-5 ａnd NCI-H23 hepatoma cell lines with IC₅₀s of 1.70, 1.90, 1.24 ａnd 1.04 μM, respectively.
c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of MDA-MB-231, SK-BR-3, HCC1954 ａnd MDA-MB-468 breast cancer cell lines with IC₅₀s of 1.45, 1.38, 1.47 ａnd 1.64 μM, respectively.
c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of HL-60, U-937, Raji, Ramos (RAl), Daudi, Jurkat, MV-4-11 ａnd MOLT-4 blood cancer cell lines with IC₅₀s of 1.95, 1.75, 1.12, 1.86, 1.25, 1.06, 1.50 ａnd 1.66 μM, respectively.
c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of ΜΙΑ PaCa-2 pancreatic cancer cell line with an IC₅₀ of 1.37 μM.
c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of HCT 116, SW620, HCT-15, RKO, HCT-8 ａnd DLD-I colorectal cancer cell lines with IC₅₀s of 1.19, 1.91, 1.32, 1.53, 1.69 ａnd 0.80 μM, respectively.
c-Myc inhibitor 8 (0-2 μM; 24 hours) inhibits cell viability of U-251 MG, U-138 MG, LOX-IMVI, SK-HEP-I ａnd OVCAR-3 cancer cell lines with IC₅₀s of 1.17, 1.34, 1.09, 1.02 ａnd 1.09 μM, respectively.

In Vivo: c-Myc inhibitor 8 (10 mg/kg; intraperitoneal injection, 3 times a week, for 10 days) inhibits tumor growth of human NCI-H1299 lung cancer mouse models.
c-Myc inhibitor 8 (30 mg/kg; intraperitoneal injection, 2 times a week, for 13 days) inhibits tumor growth of human prostate DU 145 cancer mouse models.

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