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IM176OUT05

CAS No. : 1643659-96-4

MCE 站：IM176OUT05

产品活性：IM176OUT05 是一种高溶解度的双胍。IM176OUT05 激活干细胞代谢，促进毛发再生，并在多能干细胞生成过程中增加干性诱导和维护。IM176OUT0 抑制线粒体电子传递链 (ETC) 活性，IC₅₀ 为 3.2 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Mitochondrial Metabolism

In Vitro: IM176OUT05 (0.1-10 μM; 24 hour) inhibits mitochondrial function ａnd reduces the oxygen consumption rate (OCR) as a surrogate of mitochondrial electron transport chain (ETC) activity with an IC₅₀ of 3.2μM.
IM176OUT05 (10 μM; 6 days) improves the acquisition ａnd maintenance of stem cell pluripotency of mouse ａnd human induced pluripotent stem cells (iPSCs).
IM176OUT05 (10 ａnd 100 nM) facilitates the transition of glycolytic metabolism ａnd induces of the expression of glycolysis-related genes ａnd ETC complex enzymes.

In Vivo: IM176OUT05 (200 μL, 1%; apply to the depilated area, once daily) promotes hair regrowth in mice by stimulating the progression of the hair follicle cycle to the anagen phase ａnd increasing the hair follicle number.

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