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TRAP-14

CAS No. : 137339-65-2

MCE 站：TRAP-14

产品活性：Sfllrnpndkyepf 是人工合成的 thrombin 受体激动剂肽段。

研究领域：Metabolic Enzyme/Protease

作用靶点：Thrombin

In Vitro: Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence Sfllrnpndkyepf. This peptide (TRAP-14) may signal a variety of thrombin＇s responses. Sfllrnpndkyepf, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. Sfllrnpndkyepf, corresponding to the new N-terminal region, activates ａnd induces platelet aggregation ａnd serotonin secretion. Sfllrnpndkyepf is the minimal peptide length which retains full activity in inducing [¹⁴C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, ａnd plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.

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