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Moracin C

CAS No. : 69120-06-5

MCE 站：Moracin C

产品活性：Moracin C，一种天然产物，是一种抗炎剂。Moracin C 抑制 LPS 激活的活性氧 (ROS) 和一氧化氮 (NO) 从细胞中释放。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species  |  COX

结构分类：酚类  |  多酚类  |  结构分类

来源：植物  |  桑科

In Vitro: Moracin C (1-50 μM, 24 h) inhibits LPS-activated reactive oxygen species (ROS) ａnd nitric oxide (NO) release from RAW264.7 cells.
Moracin C (1-50 μM, 2 h) inhibits mRNA ａnd protein expression of iNOS ａnd COX-2 in RAW264.7 cells.
Moracin C (1-50 μM, 2 h) inhibits pro-inflammatory cytokine (IL-1β, IL-6 ａnd TNF-α) productions in LPS-activated RAW 264.7 cells.
Moracin C (1-50 μM, 2 h) inhibits phosphorylation of p38, ERK ａnd JNK in LPS-activated RAW 264.7 cells.

In Vivo: Moracin C (100 mg/kg, oral gavage, mice) was rapidly ａnd well absorbed in the intestinal tract, ａnd was highly distributed in the gastrointestinal tract, liver, kidneys, ａnd lungs.

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