MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Antihypertensive Compound Library

MCE 站：Antihypertensive Compound Library

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, ａnd renal), ａnd reduce the risk of premature death. Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the reninangiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), ａnd to a lesser extent β-blockers. The second group of drugs works by increasing water ａnd sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics ａnd calcium channel blockers (CCBs). MCE offers a unique collection of 410 compounds with identified ａnd potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery ａnd development.

Description & Advantages:

    A unique collection of 410 antihypertensive inhibitors for high throughput screening (HTS) ａnd high content screening (HCS).

    A useful tool for the study of critical for drug discovery ａnd development.

    Target diverse, medicinally active ａnd cell permeable.

    Bioactivity ａnd safety confirmed by preclinical research ａnd clinical trials. Some have been approved by FDA.

    More detailed compound information with structure, IC50, ａnd other chemical & biological data.

    High purity ａnd quality validated by NMR ａnd LC/MS.

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。