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Dapsone
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Dapsone
CAS No. : 80-08-0
MCE 站:Dapsone
产品活性:Dapsone (4,4′-Diaminodiphenyl sulfone) 是一种具有口服活性和血脑渗透通透性的磺酰类抗生素 (antibiotic),具有抑菌、抗细菌和抗原虫活性。Dapsone 具有有效的抗麻风活性,抑制了麻风杆菌细胞提取物中叶酸的合成 (folate synthesis)。Dapsone 可用于皮肤病的研究,如麻风病、疱疹样皮炎、寻常痤疮等。
研究领域:Anti-infection | Metabolic Enzyme/Protease | Immunology/Inflammation | NF-κB
作用靶点:Antibiotic | Parasite | Bacterial | Reactive Oxygen Species
In Vitro: Dapsone are added to cell lysates (100 μg of protein) and DHPS activity assay is tested. Dapsone exhibits an IC50 of 3.0 μg/ml for E. coliC600 in DHPS activity assay, but the growth of E. coli C600 is not inhibited at 256 μg/ml Dapsone. For the recombinant strain carryingM. leprae folP1(pML101), Dapsone shows an IC50of 0.06 μg/ml and a MIC of 1 μg/ml.
In Vivo: In L. major-infected BALB/c MiceDapsone (topical treatment; 50 mg/kg; twice daily; 30 days) leads to sizes lesions around 186 mm2compared to 125 mm2for control mice. Furthermore, the amount of DAP quantified in the lesions treated with DAP cream is 9.6±8.5 g of DAP/mg of skin. However, the number of parasites found in the spleen is significantly lower in mice treated with the cream than in non-treated mice.
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热门标签:4 4′-Diaminodiphenyl sulfone