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Thio-TEPA

CAS No. : 52-24-4

MCE 站：Thio-TEPA

产品活性：Thio-TEPA 是一种 DNA 烷化剂 (DNA alkylator)，具有抗肿瘤作用。

研究领域：Cell Cycle/DNA Damage  |  Anti-infection

作用靶点：DNA Alkylator/Crosslinker  |  Bacterial  |  Antibiotic

In Vitro: Thio-TEPA exhibits alkylating activity in rat liver slice incubation. Thio-TEPA does not affect the viability of rat liver slices, ａnd is not accumulated in the slices at all doses of 2, 5, 10 mM.

In Vivo: Thio-TEPA (20 mg/kg, i.p.) with total body irradiation (TBI) enhances donor-type blood chimerism during the first 10 weeks but is not dramatically higher than that of TBI group alone. Thio-TEPA alone improves both short- ａnd long-term engraftment in mice.

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