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Metoprolol succinate

CAS No. : 98418-47-4

MCE 站：Metoprolol succinate

产品活性：Metoprolol succinate 是一种具有口服活性的、选择性的 β1-肾上腺素受体 (β1-adrenoceptor) 拮抗剂。Metoprolol succinate 具有抗炎、抗肿瘤和抗血管生成的特性。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Apoptosis

作用靶点：Adrenergic Receptor  |  Apoptosis

In Vitro: Metoprolol (0-1000 μg/mL; 24-72 h) shows cytotoxic effect on U937 ａnd MOLT-4 cells dose ａnd time dependently.

In Vivo: Metoprolol (2.5 mg/kg/h; infusion; 11 weeks) reduces proinflammatory cytokines ａnd atherosclerosis in ApoE^/ Mice.
Metoprolol (15 mg/kg/q12h; i.g.; 5 days) shows anti-inflammation ａnd anti-virus effects in murine model with coxsackievirus B3-induced viral myocarditis.
Metoprolol (2.5 mg/kg; i.v.; 3 bolus injections) significantly decreased activated caspase-9 protein expression ａnd inhibits myocardial apoptosis in coronary microembolization (CME) rats.

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