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Limantrafin

CAS No. : 218457-67-1

MCE 站：Limantrafin

产品活性：Limantrafin (CB-103) 是一种首创的，有口服活性的蛋白相互作用 (PPI) 抑制剂，靶向 NOTCH 转录复合体，具有抗肿瘤活性。是是

研究领域：Neuronal Signaling  |  Stem Cell/Wnt

作用靶点：Notch

In Vitro: Limantrafin acts as a pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex.
Limantrafin can block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines.
Limantrafin exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines.

In Vivo: Limantrafin inhibits NOTCH dependent cellular processes in mice.
Limantrafin blocks in vivo growth of PDX models of T-ALL.
Limantrafin (25 mg/kg; i.p./p.o.; 2x daily; for 2 weeks) inhibits growth of GSI/Mab resistant triple negative breast cancer.
Limantrafin exhibits anti-tumor activity in xenograft models of human T-ALL ａnd mouse mammary tumors.

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