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HPMC

CAS No. : 9004-65-3

MCE 站：HPMC

产品活性：HPMC (Hypromellose) 是用于形成溶胀溶解性基质的亲水性非离子纤维素醚。

研究领域：Others

作用靶点：Others

In Vitro: Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect. Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years. When used in matrix tablets, these polymers hydrate on contact with water to produce a viscous gel barrier within ａnd surrounding the tablet. The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration ａnd gel formation, the viscosity of the hydrated hypromellose ａnd rate of hypromellose gel erosion.

In Vivo: Punctal occlusion using hypromellose 2% is a low-cost ａnd safe additional treatment for dry eye. Fluorescein ａnd rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose. Hypromellose is effective in improving the blood glucose metabolism ａnd suppressing oxidative stress in mice fed with a high fat diet. The antihyperglycemic ａnd antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities ａnd activation of the hepatic ａnd erythrocyte antioxidant enzymes. Hypromellose may be useful as biomaterials in the development of functional food or as therapeutic agents against high fat-induced hyperglycemia ａnd oxidative stress.

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