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Hydroxystilbamidine bis(fluoroGlod)

CAS No. : 223769-64-0

MCE 站：Hydroxystilbamidine bis(fluoroGlod)

产品活性：Hydroxystilbamidine bis(methanesulfonate) 是一种能够结合 DNA 和 RNA 的染料， 也被发现是细胞核糖核酸酶的强效抑制剂。

研究领域：Others

作用靶点：Fluorescent Dye

In Vitro: It is found that the trypanocidal dye Hydroxystilbamidine bis(methanesulfonate) permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes. The heparin gradient shows some polyribosomes, whereas the Hydroxystilbamidine bis(methanesulfonate) gradient shows a remarkably large peak of very heavy polyribosomes. This peak is obtained reproducibly if Hydroxystilbamidine bis(methanesulfonate) is present before the addition of NP-40.

In Vivo: Hydroxystilbamidine bis(methanesulfonate) is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine bis(methanesulfonate) depresses the plaque response of the treated mice. Fewer PFC are observed in Hydroxystilbamidine bis(methanesulfonate)-treated mice throughout the experiment, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine bis(methanesulfonate) treated mice ａnd the control group is essentially at the background level.

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