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ALM301
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ALM301
CAS No. : 1313439-71-2
MCE 站:ALM301
产品活性:ALM301 是一种具有口服活性的高特异性 AKT 抑制剂,对 AKT1、AKT2 和 AKT3 的 IC50 分别 0.13 μM、0.09 μM 和 2.75 μM。ALM301 抑制 AKT 磷酸化,能在体外其调节下游信号 。ALM301可抑制癌细胞增殖和肿瘤生长。
研究领域:PI3K/Akt/mTOR
作用靶点:Akt
In Vitro: ALM301 (0.001-10 M; 72 h) inhibits the proliferation of cancer cells, and PI3KCA-mutant MCF-7 cells is the most sensitive; increases sub-G0 population in a dose-dependent manner.
ALM301 (1 M; 1 h) inhibits AKT phosphorylation in MCF-7 and sustains up to 48 h, with an EC50 value of 0.47 M.
In Vivo: ALM301 (10, 30 and 100 mg/kg; p.o.; single dosage) inhibits pAKTS473 in tumors and suppresses tumor growth.
ALM301 (3 or 10 mg/kg; p.o.; q.d. for 49 days) shows better tumor inhibition ability when combined with Tamoxifen (HY-13757A).
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