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S1R agonist 2 hydrochloride

CAS No. :

MCE 站：S1R agonist 2 hydrochloride

产品活性：S1R agonist 2 (Compound 8b) hydrochloride 是一种选择性 S1R 激动剂，对 S1R 和 S2R 的 K_i 分别为 1.1 nM 和 88 nM。S1R agonist 2 hydrochloride 对 ROS 和 NMDA 诱导的神经毒性具有神经保护作用。

研究领域：Neuronal Signaling

作用靶点：Sigma Receptor

In Vitro: S1R agonist 2 (Compound 8b; 0.1-5 μM) hydrochloride significantly increases the nerve growth factor (NGF) induced neurite outgrowth at all the tested concentrations in a dose-dependent manner.
S1R agonist 2 (24 h) hydrochloride significantly prevents cell damage induced by Rote (HY-B1756) when tested at the concentration of 1 μM in SHSY5Y cells.
S1R agonist 2 (0.1-5 μM; 24 h) hydrochloride demonstrates a neuroprotective effect against NMDA stimuli in SHSY5Y cells.
S1R agonist 2 (0-10 μM; 24-72 h) hydrochloride shows no cytotoxicity against A549, LoVo ａnd Panc-1 cells.

In Vivo: S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) hydrochloride does not induce embryo death (100% of embryos alive) at 10 μM, but induces the death of all zebrafish embryo at the highest dose tested (50 μM).

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