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Fisetin quarterhydrate

CAS No. :

MCE 站：Fisetin quarterhydrate

产品活性：Fisetin quarterhydrate是一种在许多水果和蔬菜中发现的天然黄酮醇，具有多种益处，如抗氧化，抗癌，神经保护作用。

研究领域：Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor  |  Epigenetics  |  Apoptosis

作用靶点：TNF Receptor  |  PPAR  |  Sirtuin

In Vitro: Fisetin quarterhydrate inhibits lipid accumulation ａnd suppresses the expression of PPARγ in 3T3-L1 cells. Fisetin quarterhydrate suppresses early stages of preadipocyte differentiation, ａnd induces expression of Sirt1. Fisetin quarterhydrate facilitates Sirt1-mediated deacetylation of PPARγ ａnd FoxO1, ａnd enhances the association of Sirt1 with the PPARγ promoter, leading to suppression of PPARγ transcriptional activity, thereby repressing adipogenesis. Fisetin quarterhydrate binds to tubulin ａnd stabilizes microtubules with binding characteristics far superior than paclitaxel. Fisetin quarterhydrate treatment of human prostate cancer cells results in robust up-regulation of microtubule associated proteins (MAP)-2 ａnd -4. Fisetin quarterhydrate significantly inhibits PCa cell proliferation, migration, ａnd invasion. Nudc, a protein associated with microtubule motor dynein/dynactin complex that regulates microtubule dynamics, is inhibited with Fisetin quarterhydrate treatment.

In Vivo: Fisetin quarterhydrate treatment to UVB exposed mice results in decreased hyperplasia ａnd reduces infiltration of inflammatory cells. Fisetin quarterhydrate treatment also reduces inflammatory mediators such as COX-2, PGE2 as well as its receptors (EP1- EP4), ａnd MPO activity. Furthermore, Fisetin quarterhydrate reduces the level of inflammatory cytokines TNFα, IL-1β ａnd IL-6 in UVB exposed skin. Fisetin quarterhydrate treatment also reduces cell proliferation markers as well as DNA damage as evidenced by increased expression of p53 ａnd p21 proteins.

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