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VEGF-CC Protein, Human (116a.a, HEK293)

MCE 站：VEGF-CC Protein, Human (116a.a, HEK293)

VEGF-C Protein, Human (116a.a, HEK293)在淋巴管的生成过程中发挥作用，主要通过其受体VEGFR-3作用于淋巴管内皮细胞，促进其生存、生长和迁移。

Synonyms: rHuVEGF-C; Vascular endothelial growth factor C; Flt4-L; VRP

Species: Human

Source: HEK293

Biological Activity: 1.The ED₅₀ is <0.5 μg/mL as measured by HMVEC human microvascular endothelial cells.
2.Measured in a cell proliferation assay using HUVEC human microvascular endothelial cells. The ED₅₀ for this effect is 2.695 g/mL, corresponding to a specific activity is 371.05 U/mg.

研究背景：The main function of VEGF-C is in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth ａnd migration. However, in addition to its effect on lymphatic vessels, it can also promote the growth of blood vessels ａnd regulate their permeability. The effect on blood vessels can be mediated via its primary receptor VEGFR-3 or its secondary receptor VEGFR-2. Apart from vascular targets, VEGF-C is also important for neural development ａnd blood pressure regulation.

蛋白编号：P49767 (A112-R227)

基因 ID：7424

产品分类：细胞因子和生长因子  |  血管内皮生长因子及受体  |  血管内皮生长因子  |  血管内皮生长因子 C

Categories：Cytokines ａnd Growth Factors  |  VEGF & VEGFR  |  VEGF  |  VEGF-C

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