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IL-1 beta 蛋白, Human (E6K, His)
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IL-1 beta Protein, Human (E6K, His)
MCE 站:IL-1 beta Protein, Human (E6K, His)
IL-1 beta 是一种强效促炎细胞因子,由单核细胞、巨噬细胞和树突状细胞表达,在炎症和免疫反应中起关键作用。IL-1 beta 以无活性的 pro-IL-1β (由 pro-Il-1b 编码) 形式产生,以响应炎症刺激。IL-1 beta Protein, Human (E6K, His) 由大肠杆菌表达产生,由 269 个氨基酸 (M1-S269) 组成,其 N 末端带有His 标签。
Synonyms: Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B
Species: Human
Source: E. coli
Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized human IL1B at 10 μg/mL (100 μl/well) can bind human IL1R1 and the EC50 is 0.198 μg/mL.
研究背景:Interleukin-1β (IL-1β) is one of the pro-inflammatory cytokines and is produced and secreted by a variety of cell types although the vast majority of studies have focussed on its production within cells of the innate immune system, such as monocytes and macrophages.
IL-1β is produced as inactive pro-IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli, including both microbial products and endogenous danger-associated molecules. IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex inflammasome. Pro-Casp-1 (encoded by pro-Casp-1), activated by the inflammasome, cleaves pro-IL-1β into the bioactive IL-1β. IL-1β acts in an autocrine/paracrine manner via the type I IL-1 receptor (IL-1R1).
IL-1β could regulate the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. IL-1β also plays a significant regulator of reproduction in females.
蛋白编号:P01584 (M1-S269, E6K)
基因 ID:3553
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-1 | 白细胞介素-1 beta | 细胞因子和生长因子 | 神经营养因子 | 白细胞介素-1 | 白细胞介素-1 beta
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-1 | IL-1 beta | Cytokines and Growth Factors | Neurotrophic Factors | IL-1 | IL-1 beta
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热门标签:Interleukin-1 beta