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GM-CSFRalpha Protein, Human (HEK293, Fc)

MCE 站：GM-CSFRalpha Protein, Human (HEK293, Fc)

GM-CSF R α是集落刺激因子2异二聚体受体的α亚基。GM-CSF R α以高特异性和低亲和力与细胞因子结合。GM-CSF R alpha与GM-CSF结合并诱导细胞分化。GM-CSF R α单克隆抗体可降低GM-CSF阳性细胞上的GM-CSFRα表达，并在类风湿性关节炎(RA)中表现出抗炎活性。GM-CSFRalpha Protein, Human (HEK293, Fc)是一种由HEK293细胞表达的重组蛋白，其C末端带有一个Fc标签，由320 (M1-G320)个氨基酸组成。

Synonyms: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GMR-alpha; CD116; CSF2RA; CSF2R; CSF2RY

Species: Human

Source: HEK293

Biological Activity: Measured by its ability to inhibit GM-CSF dependent proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is typically <15 μg/mL.

研究背景：GM-CSF R alpha is expressed on myeloid cells ａnd on some non-hemopoietic cells, such as endothelial cells, not on T cells.
The amino acid sequence of human GM-CSF R alpha protein has low homology for mouse GM-CSF R alpha protein.
GM-CSF receptor (GM-CSFR) consists of two subunits, an α-subunit, which binds the cytokine with low affinity, ａnd a larger β-subunit (beta common; βc), responsible for signaling, forming a ternary receptor complex. Signal transduction in response to the cytokines interleukin (IL)-3 ａnd IL-5 is also mediated by βc; therefore, receptor specificity is due to GM-CSFRα. After binding GM-CSF to its receptor, Janus-kinase-2 (JAK-2) is recruited to the cytoplasmic domain of the β chain, ａnd activation of JAK-2 occurs, which subsequently induces STAT-5 phosphorylation. This signaling pathway induces migration of STAT-5 dimers to the nucleus ａnd promotes the transcription of various genes such as pim-1 ａnd CIS to induce cell differentiation.
GM-CSFR α-subunit significantly increases positive synovial macrophages in the RA synovium. GM-CSFR α monoclonal antibody suppresses disease activity in the murine collagen-induced arthritis model.

蛋白编号：P15509 (M1-G320)

基因 ID：1438

产品分类：细胞因子和生长因子  |  集落刺激因子  |  粒细胞-巨噬细胞集落刺激因子受体  |  GM-CSF R alpha  |  CD 抗原  |  巨噬细胞 CD 蛋白  |  GM-CSF R alpha/CD116  |  CD 抗原  |  单核细胞 CD 蛋白  |  GM-CSF R alpha/CD116  |  CD 抗原  |  内皮细胞 CD 蛋白  |  GM-CSF R alpha/CD116

Categories：Cytokines ａnd Growth Factors  |  CSF & Receptors  |  GM-CSFR  |  GM-CSF R alpha  |  CD Antigens  |  Macrophage CD Proteins  |  GM-CSF R alpha/CD116  |  CD Antigens  |  Monocyte CD Proteins  |  GM-CSF R alpha/CD116  |  CD Antigens  |  Endothelial cell CD Proteins  |  GM-CSF R alpha/CD116

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