MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

TNF-alpha/TNFSF2 Protein, Human (Biotinylated, HEK293, His-Avi)

MCE 站：TNF-alpha/TNFSF2 Protein, Human (Biotinylated, HEK293, His-Avi)

肿瘤坏死因子α (TNF alpha)是一种有效的促炎细胞因子。TNF alpha与其受体结合，主要是TNFR1和TNFR2，然后传递信号以实现炎症和细胞死亡等生物学功能。TNF alpha通过TNFR2受体激活NF-κB通路促进癌细胞生长、侵袭和转移，但抗TNF-α抗体能显着抑制结肠炎相关癌症(CAC)小鼠的肿瘤发展。TNF alpha作为一种原神经原因子可激活SAPK/JNK通路，并能够促进神经元替代和脑修复以应对脑损伤。TNF-alpha/TNFSF2 Protein, Human (Biotinylated, HEK293, His-Avi)是一种由HEK293细胞表达的生物素化的重组蛋白，其C末端带有一个Avi标签和一个His标签，由157个(V77-L233)氨基酸组成。

Synonyms: APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2

Species: Human

Source: HEK293

Biological Activity: Immobilized Human TNF R2 mFc at 0.5 μg/mL (100μL/Well) on the plate. Dose response curve for Biotinylated Human TNF alpha His with the EC₅₀ of 3.5-6.6 ng/mL determined by ELISA.

研究背景：TNF alpha is produced by various types of cells including macrophages, monocytes, neutrophils, T cells, ａnd NK-cells.
The amino acid sequence of human TNF alpha protein has low homology between mouse, rat, bovine, cynomolgus TNF alpha protein. While, human TNF alpha shares 94.85% aa sequence identity with cynomolgus TNF alpha protein, mouse TNF alpha shares 94.47% aa sequence identity with rat TNF alpha protein.
TNF alpha exists in two forms; a type II transmembrane protein (tmTNF-α) ａnd a mature soluble protein (sTNF-α). TNF-α binds to its receptors, mainly TNFR1 ａnd TNFR2, ａnd then transmits molecular signals for biological functions such as inflammation ａnd cell death. Both sTNF-α ａnd tmTNF-α activate TNFR1, ａnd process a death domain (DD) that interacts with the TNFR1-associated death domain (TRADD) adaptor protein. The TNFR2 signaling pathway is mainly activated by tmTNF-α. TNFR1 signaling tends to be pro-inflammatory ａnd apoptotic. TNFR2 results in NF-κB ａnd MAPKs ａnd AKT activation, TNFR2 activation is associated with homeostatic bioactivities such as tissue regeneration, cell proliferation, ａnd cell survival, as well as host defense ａnd inflammation.
TNF-alpha is critical for normal immune response, abnormal secretion TNF alpha activates synovial fibroblasts, keratinocytes, osteoclasts, induces rheumatoid arthritis, inflammatory bowel disease, psoriatic arthritis (PsA), ａnd noninfectious uveitis (NIU). TNF alpha positively regulates endogenous TNF-α expression levels independently of Pgp efflux activity, induces IHF cells proliferation. TNF alpha in tissues may promote cancer growth, invasion, ａnd metastasis. Besides, TNF alpha stimulates NF-κB pathway via TNFR2 ａnd anti-TNF-α MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse. TNF alpha as a proneurogenic factor activates the SAPK/JNK pathway ａnd can facilitate neuronal replacement ａnd brain repair in response to brain injury.

蛋白编号：P01375 (V77-L233)

基因 ID：7124

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子配体  |  肿瘤坏死因子-α  |  细胞因子和生长因子  |  神经营养因子  |  肿瘤坏死因子-α  |  生物素标记蛋白

Categories：Cytokines ａnd Growth Factors  |  TNF Superfamily  |  TNF Superfamily Ligands  |  TNF-alpha  |  Cytokines ａnd Growth Factors  |  Neurotrophic Factors  |  TNF-alpha  |  Biotinylated Proteins

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。