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IL-2R alpha/CD25 Protein, Human (Biotinylated, HEK293, His-Avi)

MCE 站：IL-2R alpha/CD25 Protein, Human (Biotinylated, HEK293, His-Avi)

IL-2R alpha (CD25) 是高亲和力 IL-2 受体的重要组成部分。IL-2R alpha 增强 IL-2 与其受体复合物的结合，从而调节 T 细胞生长和其他淋巴功能。IL-2R alpha/CD25 Protein, Human (Biotinylated, HEK293, His-Avi) 是一种生物素化的重组人 IL-2R alpha 蛋白，在 HEK293 细胞中表达，由 192 个氨基酸组成 (E22-C213)，C 末端带有 His 和 Avi 标签。

Synonyms: CD25; IDDM10; IL-2 R alpha; IL2R; IL2RA; p55; TCGFR

Species: Human

Source: HEK293

Biological Activity: 1. Immobilized Biotinylated Human IL-2 R alpha His at 0.2 μg/mL (100 μL/Well) on the plate. Dose response curve for Anti-IL-2 R alpha Antibody hFc with the EC₅₀ ≤ 30.8 ng/mL determined by ELISA.
2. Immobilized Anti-IL-2 R alpha Antibody, hFc Tag at 0.2 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Human IL-2 R alpha, His Tag with the EC₅₀ ≤ 12.9 ng/mL determined by ELISA.

研究背景：IL-2R alpha (CD25) is a type I membrane protein. IL-2R alpha is expressed in peripheral activated T ａnd B cells, triple-negative thymocytes, ａnd bone marrow pre-B cells. In high tumor regulatory T (Treg) cells, IL-2R alpha is highly expressed ａnd is a potential target for Treg deletion. The expression of IL-2R alpha is undetectable on resting T cells.
The sequence of amino acids in IL-2R alpha from different species is very different (less than 85% similarity among human, rat ａnd mouse).
IL-2R alpha is an essential component of high-affinity IL-2 receptors ａnd has no signal-transducing activity per se. IL-2R alpha functions through enhancing binding of IL-2 to its receptor complex ａnd acts as a positive feedback regulator. IL-2 is a principal growth factor for T lymphocytes ａnd plays an important role in T cell immune response. IL-2R alpha transcription is regulated by three positive regulatory regions (PRRs): PRRI, PRRII ａnd PRRIII. PRRIII is an IL-2 response element.
IL-2R alpha regulates T cell growth, augments lymphocyte activation ａnd proliferation. IL-2R alpha is involved in preventing type 1 diabetes ａnd cancers.

蛋白编号：P01589 (E22-C213)

基因 ID：3559

产品分类：细胞因子和生长因子  |  白细胞介素  |  白介素-2 受体  |  白介素-2 受体 alpha  |  CD 抗原  |  T 细胞 CD 蛋白  |  CD25/IL-2R alpha  |  CD 抗原  |  B 细胞 CD 蛋白  |  CD25/IL-2R alpha  |  CD 抗原  |  NK 细胞 CD 蛋白  |  CD25/IL-2R alpha  |  生物素标记蛋白

Categories：Cytokines ａnd Growth Factors  |  Interleukin & Receptors  |  IL-2 Receptor  |  IL-2R alpha  |  CD Antigens  |  T Cell CD Proteins  |  CD25/IL-2R alpha  |  CD Antigens  |  B Cell CD Proteins  |  CD25/IL-2R alpha  |  CD Antigens  |  NK Cell CD Proteins  |  CD25/IL-2R alpha  |  Biotinylated Proteins

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