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OX40/TNFRSF4 Protein, Human(Biotinylated, HEK293, His-Avi)

MCE 站：OX40/TNFRSF4 Protein, Human(Biotinylated, HEK293, His-Avi)

OX40 (TNFRSF4) 是 OX40 配体的受体。OX40 常在 T 细胞上表达。OX40 Ligand 可以激活 OX40，从而扮演 T 细胞共刺激分子的角色。OX40-OX40 Ligand 之间的相互作用可促进效应 T 细胞存活并有效地诱导记忆 T 细胞生成，以及增强 Tfh 细胞对 B 细胞的辅助功能、促进 DCs 的分化和成熟。OX40/TNFRSF4 Protein, Human (Biotinylated, HEK293, His-Avi) 是一种由 HEK293 产生的生物素化的重组人 OX40 (L29-A216)，C 端带 Avi 和 His 标签。

Synonyms: CD134; OX40; OX40L receptor; TNFRSF4; ACT-135; Ly-70; OX40 homologue; TXGP1L; IMD16

Species: Human

Source: HEK293

Biological Activity: Measured by its binding ability in SPR assay. Human OX40 Ligand Trimer His-Flag immobilized on CM5 Chip can bind Biotinylated Human OX40 His-Avi with an affinity constant of 1.00 μM.

研究背景：OX40 (TNFRSF4), a member of TNFR superfamily, is a receptor for OX40 Ligand. OX40 is preferentially expressed by T cells, but also found in natural killer T cells, natural killer cells, neutrophils, ａnd human airway smooth muscle cells. Human OX40 shares <30% aa sequence identity with mouse ａnd rat. Mouse OX40 shares 90% aa sequence identity with rat.
OX40 Ligand can activate OX40 ａnd thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival ａnd effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, ａnd also promotes the differentiation ａnd maturation of DCs.
The interaction between OX40 Ligand with OX40 is essential for the generation of antigen-specific memory T cells, ａnd induces host antitumor immunity. But the over-upregulation of OX40 ａnd OX40L may induce abnormal activation of Tfh cells ａnd excessive production of autoantibodies, which leads to autoimmune disease.

蛋白编号：P43489 (L29-A216)

基因 ID：7293

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子受体  |  OX40  |  CD 抗原  |  T 细胞 CD 蛋白  |  CD134/OX40  |  CD 抗原  |  巨噬细胞 CD 蛋白  |  CD134/OX40  |  免疫检查点蛋白  |  刺激性免疫检查点  |  生物素标记蛋白

Categories：Cytokines ａnd Growth Factors  |  TNF Superfamily  |  TNF Receptor Superfamily  |  OX40  |  CD Antigens  |  T Cell CD Proteins  |  CD134/OX40  |  CD Antigens  |  Macrophage CD Proteins  |  CD134/OX40  |  Immune Checkpoint Proteins  |  Stimulatory Immune Checkpoint Molecules  |  Biotinylated Proteins

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