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TNFRSF11B/OPG Protein, Human (HEK293, His)

MCE 站：TNFRSF11B/OPG Protein, Human (HEK293, His)

Osteoprotegerin (OPG) 属于 TNF 受体超家族。OPG 在许多组织中表达，包括心脏、肾脏、肝脏、脾脏和骨髓。Osteoprotegerin 具有骨保护作用，在骨重塑中起关键作用。Osteoprotegerin 可与 RANKL 结合，以抑制 TNFSF11 与 RANKL 的结合，从而中和 RANKL 在破骨细胞生成中的作用。OPG 还参与癌症的许多生物过程。TNFRSF11B/OPG Protein, Human (HEK293, His) 是一种由 HEK293 产生的重组人 TNFRSF11B/OPG (E22-L401)，C 端带 6*His 标签。

Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG

Species: Human

Source: HEK293

Biological Activity: 1. The ability to inhibit TRAIL-mediated cytotoxicity using L 929 mouse fibroblast cells treated with TRAIL has an ED₅₀ value of 10.6 - 96.32 ng/mL.
2. Measured by its ability to inhibit TRAIL-mediated cytotoxicity using A549 cells in the presence of 200 ng/mL TRAIL. The ED₅₀ for this effect is 150.2 ng/mL, corresponding to a specific activity is 6.658×10³ units/mg.

研究背景：Osteoprotegerin (OPG), a glycoprotein, belongs to TNF receptor superfamily. OPG is expressed in many tissues besides osteoblasts, including heart, kidney, liver, spleen, ａnd bone marrow. Human osteoprotegerin shares <85% aa sequence identity with mouse ａnd rat. Mouse OX40 shares 94.5% aa sequence identity with rat.
Osteoprotegerin can bind to RANKL ａnd inhibit the binding between TNFSF11 ａnd RANKL, thereby neutralizing the RANKL function in osteoclastogenesis. Osteoprotegerin also protects large blood vessels from medial calcification. Increased osteoprotegerin levels have been consistently associated with the incidence ａnd prevalence of coronary artery disease. Osteoprotegerin is also involved in multiple processes of cancers, such as tumor survival, epithelial to mesenchymal transition (EMT), neo-angiogenesis, invasion, ａnd metastasis.
Osteoprotegerin plays a critical role in bone remodeling, ａnd has osteoprotective effect.

蛋白编号：O00300 (E22-L401)

基因 ID：4982

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子受体  |  骨保护蛋白

Categories：Cytokines ａnd Growth Factors  |  TNF Superfamily  |  TNF Receptor Superfamily  |  Osteoprotegerin

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