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IGFBP-4 Protein, Human (HEK293, C-His)

MCE 站：IGFBP-4 Protein, Human (HEK293, C-His)

IGFBP-4 Protein, Human为胰岛素样生长因子结合蛋白家族一员，与胰岛素样生长因子 (IGF) 结合，介导 IGF 非依赖性生物活动。

Synonyms: rHuIGF-BP-4, His; IBP-4; IGFBP-4; BP4

Species: Human

Source: HEK293

Biological Activity: 1.The ED₅₀ is <50 ng/mL, measured in a bioassay using FDC-P1 cells in the presence of 15.0 ng/ml human IGF-II.
2. Measured by its ability to inhibit the biological activity of IGF-II on MCF-7 human breast cancer cells.The ED₅₀ is 0.07882-0.1768 μg/mL in the presence of 14ng/mL rhIGF-II, corresponding to a specific activity is > 5656.1 units/mg

研究背景：The insulin-like growth factor-binding protein (IGFBP) family consists of six different protein members (IGFBP1-6) that show high inhibition for IGF-1 ａnd IGF-2. IGFBP-4 is a smallest member ａnd modulates the biologic functions by binding to IGFs. Moreover, IGFBP-4 mediates IGF-independent biologic activities. IGFBP-4 inhibits colorectal cancer, breast cancer ａnd glioblastoma cells growth. IGFBP-4 acts a crucial inflammatory mediator in the occurrence of severities acute respiratory distress syndrome, which is responsible for cancer proliferation, migration ａnd apoptosis.

蛋白编号：P22692 (D22-E258)

基因 ID：3487

产品分类：细胞因子和生长因子  |  IGF 家族  |  胰岛素样生长因子结合蛋白 4

Categories：Cytokines ａnd Growth Factors  |  IGF family  |  IGFBP-4

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