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4-1BB/TNFRSF9 Protein, Human

MCE 站：4-1BB/TNFRSF9 Protein, Human

4-1BB (CD137; TNFRSF9)，是TNFSF9/4-1BBL的受体，属于肿瘤坏死因子(TNF)受体超家族。4-1BB有助于T细胞的激活和发育，还诱导外周单核细胞增殖、向肿瘤微环境迁移。4-1BB也参与增强Nrf2和NF-κB通路介导的内皮细胞凋亡。人的4-1BB蛋白是一种表面糖蛋白，具有一个跨膜结构域(187-213 a.a.)。重组人4-1BB/TNFRSF9蛋白是4-1BB蛋白的胞外部分(E19-S184)，由大肠杆菌表达，不带标签。

Synonyms: rHu4-1BBR/TNFRSF9; CD137

Species: Human

Source: E. coli

Biological Activity: Fully biologically active when compared to standard. The biological activity is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 90 % of inibition was seen using a concentration of 1.0 μg for both 4-1BB Ligand ａnd 4-1BB Receptor.

研究背景：4-1BB, is encoded by TNFRSF9 (CD137, ILA), belongs to tumor necrosis factor (TNF) receptor superfamily. 4-1BB is a surface glycoprotein, expressed in a variety of cells, for example, T cells, B cells, natural killer (NK) cells, dendritic (DCs), eosinophils, ａnd mast cells; even a variety of tumor cells such as human leukemia cells. It is widely spread in vascular smooth muscles, tumor vessel walls, ａnd liver tissue of hepatocellular carcinoma. 4-1BB has a preference on CD8+ cells rather than CD4+ cells. It provides co-stimulatory signals ａnd activates cytotoxic effects of CD8+ T cells ａnd helps to form memory T cells. Finally, it promotes the immune system fighting against tumors. Moreover, CD137 binds CD137L to signal monocytes, increase their survival, proliferation ａnd stimulate their migration ａnd extravasation. In addition, it induces the release of various proinflammatory factors, leads to the influx of inflammatory monocytes into tissues ａnd form an inflammatory environment. Specifically, CD137 promotes the migration of monocytes/macrophages to tumor microenvironment by upregulating the expression of Fra1. It also promoted the differentiation of monocytes/macrophages into osteoclasts at the same time, thus providing a favorable microenvironment for the colonization ａnd growth of breast cancer cells in bone. It provides a promising therapeutic strategy for metastasis of breast cancer. Furthermore, CD137 signaling promotes endothelial cells (ECs) apoptosis through prooxidative ａnd proinflammatory mechanisms, mediated by Nrf2 ａnd NF-κB pathways, respectively. The homology of 4-1BB protein in human ａnd mouse was low, ａnd the sequence similarity was 56.75%.

蛋白编号：Q07011 (E19-S184)

基因 ID：3604

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子受体  |  4-1BB  |  CD 抗原  |  T 细胞 CD 蛋白  |  4-1BB/CD137  |  CD 抗原  |  巨噬细胞 CD 蛋白  |  4-1BB/CD137  |  CD 抗原  |  干细胞 CD 蛋白  |  4-1BB/CD137  |  CD 抗原  |  树突细胞 CD 蛋白  |  4-1BB/CD137  |  免疫检查点蛋白  |  刺激性免疫检查点

Categories：Cytokines ａnd Growth Factors  |  TNF Superfamily  |  TNF Receptor Superfamily  |  4-1BB  |  CD Antigens  |  T Cell CD Proteins  |  4-1BB/CD137  |  CD Antigens  |  Macrophage CD Proteins  |  4-1BB/CD137  |  CD Antigens  |  Stem Cell CD Proteins  |  4-1BB/CD137  |  CD Antigens  |  Dendritic Cell CD Proteins  |  4-1BB/CD137  |  Immune Checkpoint Proteins  |  Stimulatory Immune Checkpoint Molecules

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