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Aminopeptidase N/APN Protein, Human (HEK293, His, solution)

MCE 站：Aminopeptidase N/APN Protein, Human (HEK293, His, solution)

Aminopeptidase N/APN Protein, Human (HEK 293, His) 是一种带有 His 标签的重组氨肽酶N/APN 蛋白。APN (也称为CD13) 是一种 Zn²⁺ 依赖性膜结合外肽酶，优先降解具有 N 端中性氨基酸的蛋白质和肽。

Synonyms: rHuAminopeptidase N/APN Protein, His; Aminopeptidase N; ANPEP; AP-M; APN; AP-N; CD13 antigen; CD13; CD13APN; PEPN; PEPNhAPN

Species: Human

Source: HEK293

Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate, Ala-7-amido-4-methylcoumarin (Ala-AMC). The specific activity is 9172.6 pmol/min/g, as measured under the described conditions.

研究背景：Aminopeptidase N (APN, CD13) is a zinc-dependent ectopeptidase of the M1 family. It is a type II integral membrane protein ａnd is located on the surface of many mammalian cells like fibroblasts, epithelial ａnd myeloid cells. APN consists of 967 amino acids (aa), which can be divided into three regions. A short N-terminal region is located in the cytoplasm (aa 19), followed by a single-helix transmembrane domain (aa 1027) ａnd a large extracellular region (aa 28967). APN is involved in multiple processes. It is most widely known for its protease activity in the renin-angiotensin system, where it proteolytically converts angiotensin III to IV. In addition to its enzymatic activity, it functions as a receptor for coronaviruses ａnd has been proposed to participate in the endocytosis of cholesterol. Some of the functions of APN are mediated by protein-protein interactions.

蛋白编号：P15144 (K69-K967)

基因 ID：290

产品分类：CD 抗原  |  巨噬细胞 CD 蛋白  |  Aminopeptidase N/CD13  |  CD 抗原  |  上皮细胞 CD 蛋白  |  Aminopeptidase N/CD13  |  CD 抗原  |  内皮细胞 CD 蛋白  |  Aminopeptidase N/CD13  |  酶和调节子  |  水解酶

Categories：CD Antigens  |  Macrophage CD Proteins  |  Aminopeptidase N/CD13  |  CD Antigens  |  Epithelial cell CD Proteins  |  Aminopeptidase N/CD13  |  CD Antigens  |  Endothelial cell CD Proteins  |  Aminopeptidase N/CD13  |  Enzymes & Regulators  |  Hydrolases (EC 3)

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