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CXCL3/CINC-2 alpha Protein, Rat (CHO)

MCE 站：CXCL3/CINC-2 alpha Protein, Rat (CHO)

CXCL3 是中性粒细胞的趋化因子，属于 CXC 趋化因子亚家族。CXCL3 是一种分泌型生长因子，通过其同源受体 CXCR2 发出信号。CXCL3参与许多免疫反应，包括伤口愈合、癌症转移和血管生成。CXCL3 Protein, Rat (CHO) 是在 CHO 细胞中表达产生的，由68 个氨基酸 (R33-S100)组成。

Synonyms: rRtCXCL3; C-X-C motif chemokine 3; Cytokine-induced neutrophil chemoattractant 2; CINC-2; MIP2-alpha/beta

Species: Rat

Source: CHO

Biological Activity: The ED₅₀ is <100 ng/mL as measured by CHO-K1/Gα15/rCXCR2 cells (human Gα15 ａnd rat CXCR2 stably expressed in CHO-K1 cells).

研究背景：CXCL3 is also known as MIP-2 beta, or DCIP-1 in mouse, CINC2 in rat, ａnd GRO-gamma in humans. CXCL3 is a member of the CXC chemokine subfamily, ａnd it is subclassified as a Glu-Leu-Arg (ELR+) CXC chemokine. CXCL3 is originally identified in the supernatants of melanoma cell lines in culture, ａnd is referred to as GRO (growth-related oncogene). Previous studies have reported that CXCL3 is produced by macrophages, osteoblasts, airway epithelium, dendritic cells, synovial fibroblasts, ａnd cancers.
The amino acid sequence of human CXCL3 protein has low homology between mouse ａnd rat CXCL3 protein.
CXCL3 plays an important role in leukocyte chemotaxis, angiogenesis, tumorigenesis, ａnd cell invasion. CXCL3 exerts its functions through a number of signaling pathways including p38 MAPK, ERK1/2 MAPK ａnd JAK2/STAT3 etc., by activating CXCR2 receptor. CXCL3 is highly expressed during the number of tumorous conditions including melanoma, prostate, colorectal, aggressive breast cancer tumors, hepatocellular carcinoma (HCC) ａnd also during hepatic injury ａnd inflammation.
The cancer types affected by the action of CXCL3 (along with CXCL1 ａnd CXCL2) include prostate cancer, pancreatic cancer, melanoma, lung cancer, hepatocellular carcinoma, ａnd gastric cancer. CXCL3 facilitates adipogenic differentiation through ERK- ａnd JNK-induced induction of c/ebpb ａnd c/ebpd by autocrine/paracrine manners in adipocytes. Furthermore, CXCL3 is also associated with vascular invasion ａnd tumor capsule formation. CXCL3 plays a role in asthma severity ａnd asthmatic airway remodeling.

蛋白编号：Q10746 (R33-S100)

基因 ID：171551

产品分类：细胞因子和生长因子  |  趋化因子  |  CXC 趋化因子  |  生长调节致癌基因 γ

Categories：Cytokines ａnd Growth Factors  |  Chemokine & Receptors  |  CXC Chemokines  |  GRO-gamma

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