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CD40L/CD154/TRAP 蛋白, Human (HEK293, Tag free)
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CD40L/CD154/TRAP Protein, Human (HEK293, Tag free)
MCE 站:CD40L/CD154/TRAP Protein, Human (HEK293, Tag free)
CD40L (CD154; TRAP)是CD40 (TNFRSF5)的配体,在T细胞中产生共刺激信号而发挥上调IL-4合成的作用。CD40L在活化的CD4+ T淋巴细胞上特异性表达,参与NF-κB/MAPK信号通路。CD40L还参与B细胞的分化、成熟和凋亡。人CD40L蛋白可裂解为2种亚型,包括膜状肽(1-261a.a.)和可溶性肽(113-261 a.a.) (作为整合素的配体)。GMP重组人CD40L/CD154/TRAP蛋白(HEK293)全长149个氨基酸(M113-L261),在GMP条件下由HEK293细胞表达,不带标签。
Synonyms: CD40 Ligand; CD40-L; T-Cell Antigen Gp39; TNF-Related Activation Protein; TRAP; Tumor Necrosis Factor Ligand Superfamily Member 5; CD154; CD40LG; CD40L; TNFSF5; TRAP
Species: Human
Source: HEK293
研究背景:CD40 Ligand (CD40L; CD154; TRAP) belongs to the tumor necrosis factor (TNF) family, is the ligand for CD40/TNFRSF5, specifically expressed on activated CD4+ T-lymphocytes.
CD40L is a type II transmembrane protein on B cells triggers important signals for B cell differentiation, maturation, and apoptosis.
CD40L acts function by cross-linking on T-cells to generate a costimulatory signal and thus enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation, as well as promoting the production of interferon-γ, and TNF-α.
CD40L, binding with CD40 on antigen-presenting cells (APC), activates TNFR-associated factor 2- and IKK2-dependent pathways with stimulating I-κB kinase (IKK), increasing NF-κB DNA binding, and p65 nuclear translocation. The activation of I-κB kinase leads to strongly c-Jun N-terminal kinase activation as well as GST-I-κB and GST-p65 phosphorylation.
CD40L involves in MAPK pathways that strongly repress Bcl-6 with inducing the phosphorylation of Erk1/2, p38 and Jnk1/2 and activating IRF4 mediated by NF-κB.
CD40L also binds to and signals through several integrins, including αvβ3 and α5β1, which bind to the trimeric interface of CD40L. CD40L plays a major role in immune response and is a major target for inflammation.
CD40L is widely found in different animals, while the sequence in Human is highly similar to Rhesus macaque (98.08%), but very different from Rat and Mouse with similarities of 77.31% and 77.69%, respectively. CD40L in Human is cleaved into 2 chains of membrane form (1-261 a.a.) and soluble form (113-261 a.a.), while the soluble form derives from the membrane form by proteolytic processing. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
蛋白编号:P29965 (M113-L261)
基因 ID:959
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子配体 | CD40L 蛋白 | CD 抗原 | T 细胞 CD 蛋白 | CD40 Ligand/CD154 | CD 抗原 | 巨噬细胞 CD 蛋白 | CD40 Ligand/CD154 | 免疫检查点蛋白 | 刺激性免疫检查点
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Superfamily Ligands | CD40 Ligand | CD Antigens | T Cell CD Proteins | CD40 Ligand/CD154 | CD Antigens | Macrophage CD Proteins | CD40 Ligand/CD154 | Immune Checkpoint Proteins | Stimulatory Immune Checkpoint Molecules
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