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IL-1R2 Protein, Human (HEK293, His)

MCE 站：IL-1R2 Protein, Human (HEK293, His)

IL-1R2 是 IL-1 信号通路的竞争性内源性抑制剂。 IL-1R2 作为诱饵受体与 IL-1R1 竞争 IL-1，与 IL-1 结合后也可与 IL-1RAP 形成复合体。 IL-1R2 与多种 IL-1 介导的炎性疾病有关。IL-1R2 Protein, Human (HEK293, His) 是一种重组人 IL-1R2 蛋白，在 HEK293 细胞中表达，由 330 个氨基酸组成 (F14-E343)。C 末端带有 His 标签。

Synonyms: Interleukin-1 receptor type 2; IL-1R-2; CDw121b; IL-1R-beta; CD121b; mIL-1R2; sIL-1R2

Species: Human

Source: HEK293

Biological Activity: Immobilized Human IL-1R2, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Human IL-1 Beta, His Tag with the EC₅₀ of 15.1ng/ml determined by ELISA.

研究背景：IL-1R2 is the non-signaling type 2 interleukin-1 receptor ａnd is natively found on neutrophils, B-cells, monocytes ａnd macrophages. IL-1R2 is also expressed in breast ａnd colon cancer cells. IL-1R2 is rapidly upregulated in human regulatory T cells (Tregs). The human IL-1R2 can be cleaved into two forms: membrane form (14-398 a.a) ａnd soluble form (14-? a.a).
The sequence of amino acids in IL-1R2 from human shows low similarity (about 60%) with both mouse ａnd rat IL-1R2.
IL-1R2 contains truncated cytoplasmic domain ａnd lacks Toll-IL-1 receptor (TIR) region, making it incapable of transmembrane signaling. IL-1R2 serves as an endogenous inhibitor of IL-1 signaling. Functional IL-1 signaling requires IL-1R1 ａnd IL-1-dependent recruitment of IL-1RAP. IL-1R2 serves as a decoy receptor ａnd can compete with IL-1R1 for IL-1. IL-1R2 can also form a complex with IL-1RAP once it binds IL-1, preventing IL-1RAP from heterodimerizing with IL-1R1. Through these 2 ways, IL-1R2 blocks IL-1 signaling. Additionally, soluble IL-1R2 recruits soluble IL-1RAP with high affinity without impacting affinity for IL-1RA.
IL-1R2 inhibits IL-1 signaling ａnd has been implicated in various IL-1-mediated inflammatory diseases like arthritis, diabetes, gout ａnd so on.

蛋白编号：P27930/NP_004624.1 (F14-E343)

基因 ID：7850

产品分类：细胞因子和生长因子  |  白细胞介素  |  白介素-1 受体  |  白介素-1 受体 Ⅱ  |  CD 抗原  |  单核细胞 CD 蛋白  |  CD121b/IL-1 Receptor 2

Categories：Cytokines ａnd Growth Factors  |  Interleukin & Receptors  |  IL-1R  |  IL-1 Receptor 2 (IL-1R2)  |  CD Antigens  |  Monocyte CD Proteins  |  CD121b/IL-1 Receptor 2

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