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6Ckine/CCL21A Protein, Mouse

MCE 站：6Ckine/CCL21A Protein, Mouse

6Ckine/CCL21A Protein, Mouse是一种稳态淋巴样趋化因子，有助于T细胞和树突状细胞进入淋巴样T区。可通过趋化因子受体CCR7和CXCR3发挥作用，促进纤维化和炎症细胞因子的产生。6Ckine/CCL21A Protein, Mouse是一种由E. coli表达的重组小鼠Exodus-2/CCL21(S24-G133)。

Synonyms: C-C motif chemokine 21a; 6Ckine; TCA4; Ccl21a; Scya21; Scya21a

Species: Mouse

Source: E. coli

Biological Activity: Measured by its ability to chemoattract Mouse T lymphocytes. The ED₅₀for this effect is 26.18 ng/mL, corresponding to a specific activity is 3.820×10⁴ U/mg.

研究背景：CCL21, also known as exodus-2 ａnd secondary lymphoid chemokine (SLC), is a small cytokine belonging to the CC chemokine family ａnd is located on chromosome 9 in the human genome. It binds to glycosaminoglycan (GAG) ａnd is anchored to the surface of endothelial cells. As a chemokine, CCL21 inhibits hematopoiesis ａnd stimulates chemotaxis, ａnd is chemotactic in vitro for thymocytes ａnd activated T cells, but not for B cells, macrophages or neutrophils. At the same time, CCL21 is a potent stimulator of T cell migration ａnd adhesion, binding to the glycoprotein PSGL-1 on T cells to promote the migration of T cells to secondary lymphoid organs. CCL21 can act through chemokine receptors CCR7 ａnd CXCR3. Among them, CCR7 is a GPCR that is normally expressed by T cell subsets central memory cells, thymic T cells, B cells, mature DCs ａnd other rare cell subsets. ccl21 can function as a microglia activator in the CNS ａnd is expressed exclusively in endangered or mechanically damaged neurons.

蛋白编号：P84444 (S24-G133)

基因 ID：18829

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL21

Categories：Cytokines ａnd Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  CCL21

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