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Leptin Protein, Rat (His)

MCE 站：Leptin Protein, Rat (His)

Leptin Protein, Rat是脂肪细胞分泌的一种激素，通过抑制摄食和增加产热来帮助调节能量平衡。

Synonyms: rRtLeptin; Obesity protein (OB)

Species: Rat

Source: E. coli

Biological Activity: Fully biologically active determined by the dose dependent proliferation of MCF7 cells. The ED₅₀ for this effect is 13.06 ng/mL, corresponding to a specific activity is 7.66×10⁴ units/mg.

研究背景：A sensor (leptin production by adipose cells) monitors the size of the adipose tissue mass. Hypothalamic centers receive ａnd integrate the intensity of the leptin signal through leptin receptors (LRb). Effector systems, including the sympathetic nervous system, control the two main determinants of energy balance-energy intake ａnd energy expenditure. Recessive mutations in the leptingene are associated with massive obesity in mice ａnd humans, establishing a genetic basis for obesity. Leptin circulates in blood ａnd acts on the brain to regulate food intake ａnd energy expenditure. When fat mass falls, plasma leptin levels fall, stimulating appetite ａnd suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost. This system maintains homeostatic control of adipose tissue mass.

蛋白编号：P50596 (V22-C167)

基因 ID：25608

产品分类：细胞因子和生长因子  |  肽激素和神经肽  |  瘦素

Categories：Cytokines ａnd Growth Factors  |  Peptide Hormone & Neuropeptides  |  Leptin

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