MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

ACVR2A/Activin RIIA Protein, Human (HEK293, His, solution)

MCE 站：ACVR2A/Activin RIIA Protein, Human (HEK293, His, solution)

ACVR2A，也称为激活素 RIIA，是一种激活素 II 型受体。在配体结合时，ACVR2A 可以形成由两种 II 型和两种 I 型跨膜丝氨酸/苏氨酸激酶组成的受体复合物。ACVR2A 是 Activin A、Activin B 和 Inhibin A 的受体。ACVR2A/Activin RIIA Protein, Human (HEK293, His) 在 HEK293 细胞中产生，由 115 个氨基酸 (A20-P134) 组成，在 C 末端带有六个 His 标签。

Synonyms: rHuActivin receptor type 2A, His; ACVR-2A; Activin receptor type 2A

Species: Human

Source: HEK293

Biological Activity: The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

研究背景：ACVR2A is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2A is a receptor for Activin A, Activin B ａnd Inhibin A.
The sequence of amino acids in ACVR2A proteins from different species is very stable, which leads to the conclusion that in the process of evolution, ACVR2A has been only slightly altered, ａnd that both in humans ａnd in animals, its function is similar.
Signaling by activins ａnd BMPs is highly promiscuous, since apart from signaling through ALK4/7, the activin type II receptors (ACVR2A ａnd 2B) can interact also with several type I BMP receptors (ALK1/2/3/6), which can also form complexes with the type II BMP receptor, BMPRII. Type II receptors phosphorylate ａnd activate type I receptors which autophosphorylate, then bind ａnd activate SMAD transcriptional regulators. ACVR2A can form complexes with different type I receptors that signal either to Smad2/3 (ALK4) or to Smad1/5/8 (ALK2, ALK3, ALK6). The different type I receptors compete for binding to ACVR2A ａnd that this competition provides a mechanism that balances signaling between Activin A-mediated, ALK4-dependent Smad2/3 signaling, ａnd BMP-mediated ALK2 or ALK3-dependent signaling to Smad1/5/8. In myeloma cells, BMP-6- ａnd BMP-9-induced activation of SMAD1/5/8 through ACVR2A/ACVR2B/ALK2 is inhibited by activin A treatment.

蛋白编号：P27037 (A20-P134)

基因 ID：92

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  Activin/Inhibins Receptor  |  激活素受体 ⅡA  |  受体蛋白  |  受体丝氨酸/苏氨酸激酶  |  激活素受体 ⅡA  |  酶和调节子  |  丝氨酸/苏氨酸蛋白激酶  |  激活素受体 ⅡA

Categories：Cytokines ａnd Growth Factors  |  TGF-beta Superfamily  |  Activin/Inhibins Receptor  |  Activin A Receptor Type 2A (ACTR-IIA)  |  Receptor Proteins  |  Receptor Serine/Threonine Kinases  |  Activin A Receptor Type 2A (ACTR-IIA)  |  Enzymes & Regulators  |  Serine/Threonine Kinase Proteins  |  Activin A Receptor Type 2A (ACTR-IIA)

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。