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BMP-2 Protein, Human/Mouse/Rat (His)

MCE 站：BMP-2 Protein, Human/Mouse/Rat (His)

骨形态发生蛋白2 (BMP-2) 是一种多效性配体蛋白，属于 TNFβ 家族，并参与关键胚胎发育的血管和瓣膜稳态。BMP-2 结合 I 型受体 (ALK-2/-3/-6) 和 II 型受体 (BMPR2, ACVR2A)，以调节各种钙化类型，包括动脉粥样硬化、慢性肾病、糖尿病、瓣膜钙化。BMP-2 在人钙化瓣膜的骨化区域中由 B 淋巴细胞和 T 淋巴细胞密集浸润区域的肌成纤维细胞和前成骨细胞过度表达，是动脉粥样硬化血管钙化与正常骨形成机制之间的连接点。重组人/小鼠/大鼠 BMP-2 蛋白 (His) 长 104 个氨基酸 (Q283-R396)，由大肠杆菌表达，带有 N 端 6*His 标签。

Synonyms: rHuBMP-2; BMP2A; BMP-2A; BMP2

Species: Human;Rat;Mouse

Source: E. coli

Biological Activity: Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells ａnd the ED₅₀ for this effect is 0.1609 μg/mL, corresponding to a specific activity is 6.215×10³units/mg.

研究背景：Bone Morphogenetic Protein 2 (BMP-2) is a ligand protein with pleiotropic, belongs to TNFβ family. BMP-2 formats BMP/TGFβ signaling to involve in vascular ａnd valvular homeostasis, which is a critical process of embryonic development.
BMP-2/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 ａnd SMAD7, which are activated ａnd induced by BMP signaling ａnd switch off BMP signaling via multiple mechanisms.
BMP-2 is widely found in different animals, while the sequence in human is similar to Rat (91.86%), ａnd mouse (92.13%).
BMPs exhibits critical contributions to the pathophysiology of atherosclerosis, pulmonary vascular disease, ａnd vascular ａnd valvular calcification.
BMP-2 binds different receptor, such as type I receptors (ALK-2/-3/-6) ａnd type II receptors (BMPR2, ACVR2A), to regulate various calcification type including Atherosclerosis, Chronic Kidney Disease, Diabetes, Valvular Calcification.
BMP-2 promotes monocyte infiltration ａnd inflammation of atherosclerotic legions.
It is linked to increased plaque formation via pro-inflammatory ａnd pro-atherogenic effects, promoting oxidative stress, endothelial dysfunction ａnd osteogenic differentiation.
BMP-2 is overexpressed in ossified regions of human calcified valves by myofibroblasts ａnd pre-osteoblasts in areas densely infiltrated with B- ａnd T-lymphocytes.
And it serves as the linkers between atherosclerotic vascular calcification with mechanisms of normal bone formation.
BMP-2 induces angiogenesis, endothelial cells (ECs) proliferation, ａnd migration.
And BMP-2 also enhances the expression of the osteoblast ａnd chondrocyte ｍaster transcriptional regulator RUNX2 to promote the mineralization of cultured human coronary vascular SMCs in a manner that was dependent on oxidative stress ａnd endoplasmic reticulum (ER) stress.

蛋白编号：P12643 (Q283-R396)

基因 ID：650

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  骨形态发生蛋白  |  骨形态发生蛋白 2

Categories：Cytokines ａnd Growth Factors  |  TGF-beta Superfamily  |  Bone Morphogenetic Proteins (BMPs)  |  Bone Morphogenetic Protein 2

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