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Silybin A

CAS No. : 22888-70-6

MCE 站：Silybin A

产品活性：Silybin A (Silibinin A) 为抗癌和化疗预防化合物，能抑制细胞增殖和迁移。

研究领域：Autophagy  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB

作用靶点：Autophagy  |  Reactive Oxygen Species

结构分类：黄酮类  |  二氢黄酮醇  |  结构分类

来源：植物  |  豆科  |  Glycine soya  |  植物  |  豆科  |  瓜儿豆  |  植物  |  菊科

In Vitro: Silybin A (Silybin) significantly induced the expression of the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in both p53 wild-type ａnd p53-null cancer cell lines.
Silybin A (Silybin) induced cell death in human breast cancer cell lines MCF7 ａnd MDA-MB-231.
Silybin A (Silybin) treatment resulted in a dose- ａnd time-dependent inhibition of HCC cell viability.
Silybin A (Silybin) treatment decreased the expression of the Notch1 intracellular domain (NICD), RBP-Jκ, ａnd Hes1 proteins, upregulated the apoptosis pathway-related protein Bax, ａnd downregulated Bcl2, survivin, ａnd cyclin D1.

In Vivo: Topical application of Silybin A (Silibinin A) at the dose of 9 mg/mouse effectively suppressed oxidative stress ａnd deregulated activation of inflammatory mediators ａnd tumorigenesis.
The kidney cortex of vehicle-treated control OVE26 mice displayed greater Nox4 expression ａnd twice as much superoxide production than cortex of silybin-treated mice. The glomeruli of control OVE26 mice displayed 35% podocyte ｄrop out that was not present in the silybin-treated mice.

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