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Crocetin meglumine

CAS No. :

MCE 站：Crocetin meglumine

产品活性：Crocetin (Transcrocetin) meglumine 从藏红花 (Crocus sativus L.) 中提取的，是一种高亲和力的 NMDA 受体拮抗剂。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

结构分类：萜类  |  二萜  |  结构分类

来源：植物  |  鸢尾  |  藏红花

In Vitro: Crocetin (Transcrocetin) meglumine, a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity ａnd is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) ａnd crocin-1 (250-1000 M) reveal no negative significant changes in cellular viability. Crocetin meglumine at 10 M level does not change viability while higher concentrations (40-160 M) reduces significantly cellular viability.

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