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S-EIT hydrobromide

CAS No. : 1071-37-0

MCE 站：S-EIT hydrobromide

产品活性：S-EIT (hydrobromide) 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。

研究领域：Others

作用靶点：Biochemical Assay Reagents

In Vitro: EIT (S-ethylisothiourea) Hydrobromide is a selective inhibitor of type II NOS. EIT elicited a dose-dependent ａnd > 95% inhibition of the LPS-induced increase in plasma [NOx]. The ED50 values for EIT was 0.4 mg/kg. Pretreatment with L-arginine (but not D-arginine) prevented the mortality, while not affecting the type II NOS-dependent NO production, suggesting the toxicity may be due to inhibition of one of the other NOS isoforms (endothelial or neuronal)[1 ]. Selective NOS II antagonists attenuate but do not block shear stress-induced vasodilation in the fetal lung. Stimulation of NOS II activity, perhaps from smooth muscle cells, contributes in part to the NO-mediated fall in PVR (pulmonary vascular resistance) during shear stress-induced pulmonary vasodilation. Spleen cells stimulated with alloantigens in the presence of AMT or S-ethylisothiourea (EIT), an another selective iNOS inhibitor, produced considerably more interleukin (IL)-4 ａnd IL-10 than the cells stimulated in the absence of iNOS inhibitors. The production of Th1 cytokines IL-2 ａnd interferon (IFN)-gamma was not enhanced by the inhibition of NO synthesis. Acute administration of EIT (380 nmol/h), another inducible nitric Oxide synthase selective inhibitor, also attenuated pregnancy-induced increases in glomerular filtration rate ａnd effective renal plasma flow.

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