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1-Benzylimidazole
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1-Benzylimidazole
CAS No. : 4238-71-5
MCE 站:1-Benzylimidazole
产品活性:1-Benzyl-1H-imidazole 是一种生化试剂,可作为生物材料或有机化合物,用于生命科学相关研究。
研究领域:Others
作用靶点:Biochemical Assay Reagents
In Vitro: Benzylimidazole is a selective inhibitor of thromboxane synthase and a stimulator of UDP-glucuronosyltransferase. Thromboxane synthase is a cytochrome P450 enzyme. The cytochrome P450 proteins have been involved in catalyzing many reactions invol ved in drug metabolism and synthesis of cholesterol, steroids , and other lipids. The enzyme plays an important role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. The gene expresses two transcript variants. 1-Benzylimidazole selectively inhibited the activity of thrombus Boxane synthase. 1-Benzylimidazole reduced TXB2 levels and increased blood flow in ischemia-reperfusion injury of rat brain. In male Wistar rats, gastrically administration of 1-benzylimidazole (25, 75 and 100 mg/kg/day) caused a dose-dependent hepatitis. 1-Benzylimidazole decreased the plasma level in triglycerides by 6070%. 1-benzylimidazole stimulated three distinct forms of UDP-glucuronosyltransferase. 1-benzylimidazole significantly increased the activities towards 4-methylumbelliierone, 1-naphthol, morphine or a monoterpenoid alcohol, nopol. Benzylimidazole increased hepatocellular CYP1A catalytic activity and CYP1A mRNA in a concentration-dependent way.
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热门标签:1benzylimidazole 1