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7-Methoxy-1-tetralone
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7-Methoxy-1-tetralone
CAS No. : 6836-19-7
MCE 站:7-Methoxy-1-tetralone
产品活性:7-Methoxy-1-tetralone 是一种强效的抗肿瘤试剂。7-Methoxy-1-tetralone 抑制癌细胞增殖和迁徙,并诱导肝细胞癌细胞 (HCC) 凋亡 (apoptosis)。7-Methoxy-1-tetralone 能够降低 NF-κB、基质金属肽酶 2 (MMP2)/MMP9 和 p-AKT 的蛋白水平。7-Methoxy-1-tetralone 在裸鼠体内具有抗肿瘤活性,对体重和肝脾脏器指数没有影响。
研究领域:Apoptosis | NF-κB | Protein Tyrosine Kinase/RTK | PI3K/Akt/mTOR | Metabolic Enzyme/Protease
作用靶点:Apoptosis | NF-κB | c-Met/HGFR | Akt | MMP
In Vitro: 7-Methoxy-1-tetralone (31.25-1000 μM; 48 h) inhibits proliferative activity of LO2 and HepG2 cells.
7-Methoxy-1-tetralone (40 μM, 100 μM, and 250 μM; 48 h) induces HepG2 cell apoptosis, and decreases the protein expression levels of c-Met, p-AKT, AKT, NF-κB, MMP2, and MMP9 in cells.
In Vivo: 7-Methoxy-1-tetralone (80, 120, or 160 mg/kg/d; ip; 19 doses in total) inhibits tumor growth in subcutaneously implanted tumor model with HepG2 cells.
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