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Autoimmune Disease Compound Library
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Autoimmune Disease Compound Library
MCE 站:Autoimmune Disease Compound Library
Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A). MCE designs a unique collection of 419 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.
Description & Advantages:
A unique collection of 419 small molecules related to autoimmune diseases for high throughput screening (HTS) and high content screening (HCS).
Targets such as TNF Receptor, IFNAR, JAK, Btk, TLR, and more.
A useful tool for drug discovery.
Target diverse, medicinally active and cell permeable.
Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
More detailed compound information with structure, IC50, and other chemical & biological data.
High purity and quality validated by NMR and LC/MS.
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• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物;
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