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Dopamine Receptor Compound Library

MCE 站：Dopamine Receptor Compound Library

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force ａnd cognition. The role of DA is mediated by D1-type (D1, D5) ａnd D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic ａnd extrasynaptic, projection neurons ａnd interneurons. Each receptor has a different function. D1 ａnd D5 receptors couple with G stimulation sites ａnd activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase ａnd activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated ａnd neurotransmitter-gated channels, cytoplasmic enzymes, ａnd transcription factors. Dopamine receptor plays an important role in daily life.MCE designs a unique collection of 180 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Description & Advantages:

   A unique collection of 180 small molecules related to dopamine receptor for high throughput screening (HTS) ａnd high content screening (HCS).

   A useful tool for dopamine receptor-related drug discovery ａnd disease research.

   Structurally diverse, medicinally active ａnd cell permeable.

   Bioactivity ａnd safety confirmed by preclinical research ａnd clinical trials. Some compounds have been approved by FDA.

   More detailed compound information with structure, IC50, ａnd other chemical & biological data.

   High purity ａnd quality validated by NMR ａnd LC/MS.

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。