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BDNF Protein, Human (R125A, R127A, R128A, solution)

MCE 站：BDNF Protein, Human (R125A, R127A, R128A, solution)

脑源性神经营养因子 (Brain Derived Neurotrophic Factor, BDNF) 是属于 NGF-β 家族的神经营养因子。BDNF 可以与其受体 TrkB 结合，具有高亲和力，并激活信号转导级联反应 (IRS1/2、PI3K、Akt)。BDNF 也可以与 p75NTR 结合，但对 p75NTR 受体的亲和力低于对 TrkB 的亲和力。BDNF 是一种神经递质调节剂，在发育过程中对神经元群的成熟、存活和分化至关重要。BDNF 还参与调节神经元可塑性，这对学习和记忆功能至关重要。BDNF 广泛表达于中枢神经系统。BDNF Protein, Human (R125A,R127A,R128A) 是一种由 E.coli 产生的重组人 BDNF (A19-R247)，不带标签，且含有 R125A, R127A, R128A 突变。

Synonyms: Brain-derived neurotrophic factor; BDNF; Abrineurin; ProBDNF

Species: Human

Source: E. coli

研究背景：BDNF, a neurotrophin that belongs to NGF-beta family. BDNF is widely expressed in the CNS, gut ａnd other tissues. BDNF regulates neurodevelopmental processes, including maturation, survival ａnd differentiation of neuronal populations, ａnd synaptic plasticity.
BDNF can bind to its high affinity receptor TrkB ａnd activates signal transduction cascades (IRS1/2, PI3K, Akt), thereby inducing increased Ca²⁺ intake ａnd phosphorylation of transcription factors. BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. The activation of p75NTR increases apoptotic ａnd inflammatory signaling in neurons ａnd glial cells by activation of c-Jun N-terminal kinases (JNK) ａnd NF-κB expression, respectively. In human, decreased levels of BDNF are associated with neurodegenerative diseases (such as Parkinson＇s disease ａnd Alzheimer＇s disease) ａnd type 2 diabetes mellitus. Human BDNF shares >97% aa sequence identity with mouse ａnd rat. Rat BDNF shares >99% aa sequence identity with mouse.
BDNF is a neurotransmitter modulator which is vital in maturation, survival ａnd differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning ａnd memory.

蛋白编号：P23560 (A19-R247, R125A, R127A, R128A)

基因 ID：627

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