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Salvianolic acid C

CAS No. : 115841-09-3

MCE 站：Salvianolic acid C

产品活性：Salvianolic acid C 是细胞色素 P4502C8 (CYP2C8) 的非竞争性抑制剂和细胞色素 P4502J2 (CYP2J2) 中等强度的混合抑制剂，其对 CYP2C8 和 CYP2J2 的 K_i 值分别为 4.82 μM 和 5.75 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Cytochrome P450

结构分类：酚类  |  多酚类  |  酮、醛、酸  |  结构分类

来源：植物  |  菊科  |  泥胡菜  |  植物  |  唇形科

In Vitro: Salvianolic acid C is a noncompetitive CYP2C8 inhibitor ａnd a moderate mixed inhibitor of CYP2J2, with K_is of 4.82, 5.75 μM for CYP2C8 ａnd CYP2J2, respectively. 1 ａnd 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 ａnd IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF κB activation. Salvianolic acid C also increases the expression of Nrf2 ａnd HO-1 in BV2 microglial cells.

In Vivo: Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 ａnd 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β ａnd IL-6 levels compared with the model group. The iNOS ａnd COX-2 levels in rat brain cortex ａnd hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex ａnd hippocampus regions. Salvianolic acid C (5, 10 ａnd 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 ａnd NQO1 levels in rat brain cortex ａnd hippocampus.

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