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D-erythro-Sphingosine

CAS No. : 123-78-4

MCE 站：D-erythro-Sphingosine

产品活性：D-erythro-Sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶活化剂，EC₅₀ 为 8 μM。D-erythro-Sphingosine 抑制蛋白激酶 C (PKC)。D-erythro-Sphingosine (Erythrosphingosine) 也是一种 PP2A 激活剂。

研究领域：Epigenetics  |  TGF-beta/Smad  |  Metabolic Enzyme/Protease

作用靶点：PKC  |  Phosphatase  |  Endogenous Metabolite

结构分类：其他类  |  结构分类

In Vitro: A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM ａnd a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, ａnd a preference for sphingosines over ihydrosphingosines. D-erythro-Sphingosine inhibits protein kinase C in vitro. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation ａnd several signal transduction pathways, ａnd exhibits antitumor promoter activities in various mammalian cells.

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