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3-Deazaadenosine hydrochloride

CAS No. : 86583-19-9

MCE 站：3-Deazaadenosine hydrochloride

产品活性：3-Deazaadenosine (hydrochloride) 是一种 S-腺苷高半胱氨酸水解酶 (S-adenosylhomocysteine hydrolase) 抑制剂，K_i 值为 3.9 M；3-Deazaadenosine (hydrochloride) 具有抗炎、抗增殖、抗 HIV 等活性。

研究领域：Anti-infection

作用靶点：HIV

In Vitro: 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K_i of 3.9 μM. 3-Deazaadenosine shows anti-HIV effect, ａnd inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 ａnd A018) with IC₅₀s of 0.15 ａnd 0.20 μM, respectively.
3-Deazaadenosine (1-100 μM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, ａnd causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 μM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, ａnd such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 μM) dose-dependently inhibits the phosphorylation of Raf ａnd ERK, protein-dependent kinase 1, protein kinase B (Akt), ａnd forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 μM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.

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