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Diethyl-pythiDC

CAS No. : 1821370-70-0

MCE 站：Diethyl-pythiDC

产品活性：Diethyl-pythiDC 是胶原蛋白脯氨酰4-羟化酶 (CP4Hs) 抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：MMP

In Vitro: Diethyl-pythiDC inhibits CP4H activity in cultured cells at concentrations that do not cause iron deficiency. MDA-MB-231 cells are treated with biheteroaryl dicarboxylates, ａnd assayed for cytotoxicity ａnd indicators of iron deficiency. None of the esterified biheteroaryl dicarboxylates exhibited cytotoxic activity at high micromolar concentrations. Cells treated with dihydroxybenzoate (EDHB demonstrate a strong iron-deficient phenotype. In contrast, cells treated with Diethyl-pythiDC (Diethyl pythiDC) appear to be normal at concentrations as high as 500 μM. Treatment with Diethyl-pythiDC ａnd low levels of diethyl pyimDC does not affect the level of TfR, HIF-1α, or ferritin.

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