MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Mavacamten

CAS No. : 1642288-47-8

MCE 站：Mavacamten

产品活性：Mavacamten (MYK461) 是具有口服活性的心肌肌球蛋白的调节剂，其在牛心脏和人心脏中的 IC₅₀ 值分别为 490，711 nM。

研究领域：Cytoskeleton

作用靶点：Myosin

In Vitro: Mavacamten is found to have an IC₅₀ value of 490 nM in the bovine system, 711 nM in the human system, ａnd 2140 nM in the rabbit system, indicating selectivity of >4-fold for cardiac myosin.

In Vivo: Treatment with Mavacamten reduces FS from 52±3% to 38±7%. Treatment with Mavacamten reduces FS from 81±7% to 60±13%, corresponding to a relative reduction of 25%. Across all measurements there is a linear correlation between FS ａnd Mavacamten plasma concentrations with each 100 ng/mL increase in Mavacamten concentration lowering FS by 4.9%. Mavacamten reduces contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain. Chronic administration of Mavacamten suppresses the development of ventricular hypertrophy, cardiomyocyte disarray, ａnd myocardial fibrosis ａnd attenuates hypertrophic ａnd profibrotic gene expression in mice harboring heterozygous human mutations in the myosin heavy chain.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Anti-COVID-19 Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Rare Diseases Drug Library  |  Myosin V-IN-1  |  ATM-3507 trihydrochloride  |  Omecamtiv mecarbil-d₈  |  HA-100 hydrochloride  |  Danicamtiv  |  Blebbistatin  |  MT-134  |  JB002  |  16-38-Thymosin β4 (cattle) (TFA)  |  para-Nitroblebbistatin  |  Kemptamide  |  MLCK inhibitor peptide 18  |  W-7 hydrochloride  |  BTS  |  JB062  |  Pentachloropseudilin  |  Myosin Light Chain Kinase Substrate (smooth muscle)  |  Sevasemten  |  Aficamten  |  MPH-220  |  ML-7 hydrochloride  |  Para-aminoblebbistatin  |  JB061

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。