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LY2828360

CAS No. : 1231220-79-3

MCE 站：LY2828360

产品活性：LY2828360 是一个作用缓慢但很有效的 G 蛋白偏倚的大麻素受体 2 (CB₂) 激动剂，能够抑制 cAMP 的积累并激活 ERK1/2 通路。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Cannabinoid Receptor

In Vivo: In WT mice, acute systemic administration of LY2828360 suppresses paclitaxel-induced mechanical ａnd cold allodynia in a dose-dependent manner. LY2828360 produces time-dependent suppressions of paclitaxel-evoked mechanical ａnd cold hypersensitivities ａnd suppression of allodynia is maintained for at least 4.5 h post-injection relative to drug pre-injection levels. At 24 h post-injection, paclitaxel-induced mechanical allodynia has returned to drug pre-injection levels of hypersensitivity. Residual suppression of cold allodynia was absent by 72 h post LY2828360 treatment. Previously chronic administration of LY2828360 blocks the development of tolerance to the antiallodynic effects of morphine in WT but not in CB₂KO mice. Chronic LY2828360 treatment suppresses paclitaxel-induced mechanical ａnd cold allodynia in WT mice but not in CB₂KO mice previously render tolerant to morphine.

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