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NGFRProtein, Mouse (HEK293, His)

MCE 站：NGFRProtein, Mouse (HEK293, His)

Nerve Growth Factor Receptor (NGFR)也称为CD271、p75NTR、TNFRSF16，是神经营养蛋白家族的跨膜低亲和力受体。NGFR没有内在的酪氨酸激酶活性。NGFR可作为肿瘤抑制因子，负向调节细胞生长和增殖。NGF-NGFR激活NF-κB，从而抑制细胞凋亡，增加神经鞘瘤和乳腺癌细胞的存活率。NGFRProtein, Mouse (HEK293, His)是一种由HEK293细胞表达的重组蛋白，其C末端带有His标签，由243 (M1-N243)个氨基酸组成。

Synonyms: NGFR; Gp80-LNGFR; p75 ICD; CD271; TNFRSF16

Species: Mouse

Source: HEK293

Biological Activity: Measured by its ability to inhibit beta-NGF-dependent proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 3.772 g/mL in the presence of 2 ng/mL of recombinant human beta-NGF, corresponding to a specific activity is 2.686×10² units/mg.

研究背景：Nerve Growth Factor Receptor (NGFR) is expressed not only in nervous tissue, but also in non-neuronal normal ａnd cancer cells, such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa ａnd hair follicles, prostate basal cells ａnd myoepithelial cells.
Human NGFR shares 92.45% aa sequence identity with mouse NGFR protein ａnd 92.42% aa sequence identity with rat NGFR protein.
Nerve Growth Factor Receptor (NGFR) is a type-I transmembrane protein, a typical structure of the TNFR superfamily ａnd devoid of intrinsic catalytic activity. NGFR signaling involves activation of NF-kB (Rel/NF-kB transcription factors) ａnd the phosphorylation of the transcription factor c-Jun kinase (JNK), as well as increased production of ceramide, leading to gene transcription or programmed cell death.
NGFR induces p53-dependent apoptosis ａnd cell growth arrest as well as suppressed tumor growth. The low-affinity nerve growth factor receptor (NGFR) p75NGFR induces apoptosis in the absence of nerve growth factor (NGF) binding but enhances neural survival when bound by NGF. NGFR enhances beta-amyloid peptide toxicity. NGFR signal can induce the subsequent downregulation of melanoma antigens ａnd eventually suppress CTL activation.

蛋白编号：Q9Z0W1 (K32-N253)

基因 ID：18053

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