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Gigantol isomer-1

CAS No. : 67884-30-4

MCE 站：Gigantol isomer-1

产品活性：Gigantol isomer-1 是一种来自石斛的联苄基化合物。Gigantol isomer-1 具有抗肿瘤活性。Gigantol isomer-1 是 Wnt/β-catenin 通路的抑制剂。

研究领域：Stem Cell/Wnt

作用靶点：Wnt

In Vitro: Gigantol isomer-1 decreases the level of phosphorylated LRP6 ａnd cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 ａnd MDA-MB-468 cells, treatment with Gigantol isomer-1 reduces the level of phosphorylated LRP6. Gigantol isomer-1 significantly inhibits the proliferation ａnd induces apoptosis of the HepG2 cells. Gigantol isomer-1 at concentrations of 1, 40 ａnd 150 μM markedly decreases the cell viability by 11.7, 30.0 ａnd 56.4% at 24 h ａnd 21.1, 66.8 ａnd 85.5% at 48 h, respectively. The IC₅₀ value is 9.30 μM.

In Vivo: LDD ａnd Gigantol isomer-1 (25100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice ａnd decreased carrageenaninduced inflammation in rats.

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