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3-Hydroxyanthranilic acid-d3

CAS No. : 1794970-56-1

MCE 站：3-Hydroxyanthranilic acid-d3

产品活性：3-Hydroxyanthranilic acid-d₃ 是氘代标记的 3-Hydroxyanthranilic acid (HY-W001171)。

研究领域：Metabolic Enzyme/Protease  |  Others

作用靶点：Endogenous Metabolite  |  Isotope-Labeled Compounds

In Vitro: Stable or radioisotope-labeled compounds allow precise tracking ａnd quantification of individual atoms in metabolic pathways. Stable isotopes generally do not change molecular properties but may slightly affect metabolic kinetics; radioactive isotopes may interfere with cells. Markers can distinguish endogenous ａnd exogenous metabolites, reduce false positives, ａnd are beneficial to quantification ａnd reconstruction of metabolic pathways.
In cell culture or enzymatic reactions, the use of isotope markers can precisely control the concentration ａnd exposure time, making it easy to study metabolic reactions ａnd enzyme activities. Through stable isotope analytical metabolomics (SIRM), cellular metabolic networks can be studied, key metabolic nodes ａnd regulatory mechanisms can be identified, ａnd targets can be provided for compound development.
Isotope-labeled compounds can be used in competition binding experiments to evaluate the affinity ａnd binding kinetics of compounds to receptors to help optimize design. Stable isotope labels are used as internal standards in mass spectrometry analysis to improve analysis accuracy ａnd reproducibility ａnd reduce matrix effect interference.

In Vivo: Isotopic labels can non-invasively track the distribution, transformation ａnd clearance of compounds ａnd their metabolites in the body through techniques such as mass spectrometry (MS) ａnd nuclear magnetic resonance (NMR), which is beneficial to the study of pharmacometabolic kinetics (ADME).
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms ａnd evaluate unexpected side effects, improving the accuracy ａnd efficiency of clinical research.

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